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Welcome to MTi

 



The UMRS Paris Diderot-Inserm 973 under the direction of Dr. BO Villoutreix (DR Inserm) is composed of three teams based on the PRG campus (UFR Life Sciences), and will incorporate the coming months members working at the IUH Hospital Saint Louis and the Center for clinical investigation of the hospital . The unit works on the development of new in silico approaches that assist the rational design of new therapeutic molecules and pharmacological probes.

Structural bioinformatics and chemoinformatics are well-established research disciplines with numerous applications in the area of Life and Health Sciences as further highlighted by the attribution of the 2013 Nobel prize to 3 pioneer scientists working on these topics. (See additional comments about drug design and in silico methods)

At present, our main goal is to develop novel in silico protocols and new algorithms that assist the design of “high quality” peptides and low molecular weight chemicals with timely applications essentially in the areas of cancer, rare diseases and cardiovascular diseases.
« High quality » means that important efforts in terms of compound profiling (systems pharmacology) and ADME-Tox predictions to avoid possible adverse effects early in the drug discovery process are being actively considered and that we work also on compound optimization protocols.
The strategy to achieve our main objective considering our skills, the size of the lab and the national and international contexts, and suggestions from an external advisory board is to focus our efforts on 3 main interrelated research axes.

To increase our chance of success, we re-organized our research unit and created 3 teams, each one focusing on one research axis. The 3 teams are focusing on:

 

Our research unit is also associated to two national technological platforms :




mtilab

We are committed to research and trainings in the area of computational biology and chemistry, and work along the strategic orientations defined by the French government, Inserm (French public organization dedicated to medical research) and Paris Diderot-Paris 7 University.
 

We thank ANR, AnrS, INSERM,Paris-Diderot and INCa for supports

Molécules Thérapeutiques in silico (MTi)
Université Paris Diderot - Inserm UMR-S 973
Bât Lamarck A, 4th & 5th floor , Mailbox 7113
35 Rue Hélène Brion
75205 PARIS CEDEX 13

Phone : (331) 57 27 83 86
Fax: : (331) 57 27 83 72

Molécules Thérapeutiques in silico (MTi)
Université Paris Diderot - Inserm UMR-S 973
Bât Lamarck A, 4th & 5th floor , Mailbox 7113
35 Rue Hélène Brion
75205 PARIS CEDEX 13

Phone : (331) 57 27 83 86
Fax: : (331) 57 27 83 72